Minocycline relieves depressive-like behaviors in rats with bone cancer pain by inhibiting microglia activation in hippocampus

J Dai, Z Ding, J Zhang, W Xu, Q Guo, W Zou… - Anesthesia & …, 2019 - journals.lww.com
… that minocycline could attenuate pain and depressive-like behavior in an animal model of …
activation of microglia and the expressions of proinflammatory cytokines tumor necrosis factor-…

Microglia and p38 MAPK Inhibitors Suppress Development of Mechanical Allodynia in Both Sexes in a Mouse Model of Antiretroviral-Induced Neuropathic Pain

MW Alhadlaq, W Masocha - International Journal of Molecular Sciences, 2023 - mdpi.com
… increased release of pro-inflammatory cytokines, such … minocycline reduced mechanical
allodynia in animal models through microglia inhibition. Mechanical allodynia was attenuated

Local sympathectomy promotes anti-inflammatory responses and relief of paclitaxel-induced mechanical and cold allodynia in mice

R Tonello, W Xie, SH Lee, M Wang, X Liu… - …, 2020 - pubs.asahq.org
… Similarly, minocycline, an antibiotic that inhibits monocyte/… pain-like behaviors by facilitating
nociceptive transmission. … and attenuation of paclitaxel-induced mechanical allodynia by …

[HTML][HTML] Intra-CA1 administration of minocycline alters the expression of inflammation-related genes in hippocampus of CCI rats

L He, R Xu, Y Chen, X Liu, Y Pan, S Cao… - Frontiers in Molecular …, 2019 - frontiersin.org
… of CCI-induced mechanical allodynia. We identified 790 … by pain responses in different
animal models of neuropathic … A high dose of minocycline attenuated reductions in O1- and O4-…

Magnetic Field Exposure Modulates the Anti-Inflammatory Efficiency of Minocycline in Rats with Peripheral Acute Inflammation.

T Mert, M Sahin, E Sahin… - Alternative Therapies in …, 2020 - search.ebscohost.com
Background and Objective: Microglial activation in spinal cord is key contributor and its inhibition
by Minocycline (MCN) can result in anti-inflammatory actions. Effect of pulsed magnetic …

Minocycline alleviates nociceptive response through modulating the expression of NR2B subunit of NMDA receptor in spinal cord of rat model of painful diabetic …

CAN Ismail, AK Ghazali, R Suppian… - Journal of Diabetes & …, 2021 - Springer
… such as mechanical allodynia and hyperalgesia [14, 15]. A similar finding … of pro-inflammatory
cytokines released by the activated microglia during the pathogenesis of neuropathic pain […

Minocycline abrogates individual differences in nerve injury-evoked affective disturbances in male rats and prevents associated supraspinal neuroinflammation

JA O'Brien, PJ Austin - 2023 - researchsquare.com
… Ledeboer A, Sloane EM, Milligan ED et al (2005) Minocycline attenuates mechanical
allodynia and proin ammatory cytokine expression in rat models of pain facilitation. Pain 115:71–83…

Effect of Electroacupuncture at Fengchi on Facial Allodynia, Microglial Activation, and Microglia–Neuron Interaction in a Rat Model of Migraine

P Pei, S Cui, S Zhang, S Hu, L Wang, W Yang - Brain sciences, 2022 - mdpi.com
… -1, proinflammatory cytokines, and cytokine receptors in the … attenuated in the SA group
(model & SA: p > 0.05 for both). … -like effect of minocycline on microglia activation in migraine rat. …

Neuroimmune mechanisms of pain: basic science and potential therapeutic modulators

JSY Lim, PCA Kam - Anaesthesia and Intensive Care, 2020 - journals.sagepub.com
… glial inhibitor, inhibits mechanical allodynia in animal models. … Minocycline suppressed
glial priming in an animal study … , and attenuates neuropathic pain in a rat model. However, a …

β-Caryophyllene, a CB2-receptor-selective phytocannabinoid, suppresses mechanical allodynia in a mouse model of antiretroviral-induced neuropathic pain

E Aly, MA Khajah, W Masocha - Molecules, 2019 - mdpi.com
… in animal models of paclitaxel-induced neuropathic pain and … , BCP attenuated the ddC-established
mechanical allodynia. … minocycline, which inhibits inflammatory cytokine production